| 1543 | Nicolaus Copernicus publishes De Revolutionibus (translation) with dedication to the Pope, dies. |
| 1572 | Tycho Brahe observes supernova, demonstrates lack of parallax, becomes famous. |
| 1576-97 | Tycho observes, plots positions of planets at Uraniborg Observatory and Stjerneborg Observatory on isle of Hveen, Denmark (now Ven, Sweden). Galileo Galilei does experiments in mechanics, becomes professor of mathematics at Pisa in 1589 at age 25. |
| 1600 | Johannes Kepler, 29, meets Tycho, 53, in Prague. |
| 1601 | Tycho dies. Kepler acquires data, becomes Imperial Mathematician. |
| 1604 | Kepler observes supernova, takes time out from study of orbits. |
| 1609 | Kepler publishes Astronomia Nova (A New Astronomy) containing 1st and 2nd laws. Galileo builds telescope and observes sky. |
| 1610 | Galileo publishes Sidereus Nuncius (Starry Messenger or Message). Kepler defends it without having seen telescope. |
| 1616 | Galileo travels from Florence to Rome to convert Church to Copernican system. Result is that Copernicus is put on Index of forbidden books and Galileo is prohibited from teaching or defending heliocentric model. |
| 1619 | Kepler publishes Harmonices Mundi (Harmony of the World) containing 3rd law.
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| 1629-32 | Galileo publishes Dialogue Concerning the Two Chief World Systems. Five months after publication it is banned and Galileo summoned to Rome. He goes. Kepler dies in 1630. |
| 1633 | Galileo is convicted of disobedience, confined to house arrest, forbidden to publish anything. |
| 1638 | Galileo publishes Two New Sciences in Holland. |
| 1642-43 | Galileo dies. Isaac Newton is born.
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| 1664-65 | Plague closes Cambridge. Newton goes to country, discovers laws of motion and gravity, explains orbits, invents calculus, makes discoveries in optics. |
| 1682 | Edmond Halley, with Newton's aid, has plotted orbits of comets. He shows that comet of 1682 is same as that of 1531 and 1607, predicts return in 1758. |
| 1687 |
Newton publishes Principia (Mathematical Principles of Natural Philosophy) containing laws of motion and gravitation and explaining motions in the sky and on earth with the same laws. |
| 1727 | Newton dies. Alexander Pope writes
Nature and Nature's laws lay hid in night;
God said, Let Newton be! and all was light. |